Experimental Studies on the Development of the Mandibular Arch in Amblystoma Punctatum

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Abstract
All expts. were performed on embryos of Ambystoma punctatum in the early tail bud stages. Unilateral rotation of the mandibular arch through 180 degrees (reversal of both antero-posterior and dorso-ventral axes) resulted in distortion of the arch. Whereas all elements normally found in the region were present, their topographic arrangement was disturbed. Healing in this region was also abnormal. Reversing the antero-posterior axis only did not result in such severe abnormalities. When the mandibular arch was transplanted to the anterior somite area, its development varied considerably. If the oral epithelium was included in the graft, teeth developed. The donor embryo, however, did not regenerate a new mandibular arch. When incisions were made in the midline and posterior margins of the mandibular arch, gross abnormalities developed in a large percentage of the embryos. However, healing occurred normally in almost all cases when incisions were along the other margins of the mandibular arch. The results of all of these expts. show that the mandibular arch does not possess the power of complete restitution.

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