Blast transformation in vivo and in vitro in carbamazepin hypersensitivity.

  • 1 September 1971
    • journal article
    • Vol. 9  (3) , 429-35
Abstract
A case is reported in which the number of proliferating blast-like cells substantially increased in peripheral blood during hypersensitivity reaction to carbamazepin (`Tegretol'). The patient's lymphocytes subsequently transformed in vitro into blasts in the presence of carbamazepin. In provocation tests, two patients with carbamazepin hypersensitivity showed a significant increase in proliferating blasts in the peripheral blood.