EVALUATION OF A HEXAMETHYLMELAMINE AND 5-FLUOROURACIL COMBINATION IN TREATMENT OF ADVANCED OVARIAN CARCINOMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 61  (9) , 1691-1693
Abstract
The combination of 2 nonalkylating agents, hexamethylmelamine (HMM) and 5-fluorouracil (5-FU), was evaluated in 14 patients with advanced ovarian carcinoma. Nine patients were treated previously with alkylating agents. The overall response rate was 36% which is not greater than could be expected with HMM or 5-FU alone. The median survival of the 5 responders was > 24 mo. Treatment had to be discontinued in 5 of 14 patients due to excessive toxicity. Although the toxic effects were predominantly gastrointestinal, unpredictable hematopoietic and neurotoxic effects were observed.

This publication has 2 references indexed in Scilit: