Influence of Hemolysis on the Measurement of S-100β Protein and Neuron-specific Enolase Plasma Concentrations during Coronary Artery Bypass Grafting

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Abstract
Cerebral injury is an important complication after cardiovascular surgery. The neurological events usually are diagnosed using rather crude psychometric tests and clinical observations (1). Biological markers have been proposed to detect cerebral damage during cardiac surgery, e.g., the creatine kinase BB isoform or neuron-specific enolase (NSE). Because of its neurospecificity, the γγ isoform of enolase is of particular interest. Measurements in biological fluids use γ-subunit-specific immunoassays. Because of the abundance of the αγ isoform of enolase in erythrocytes, systemic NSE values may be falsely increased by the frequent hemolysis that occurs during surgery (2)(3).