HIV Vaccine Trial Justified

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Abstract
In this Policy Forum, the [authors][1] respond to [ Burton et al .][2] by asserting that the ongoing efficacy trial of ALVAC-HIV (vCP1521) and AIDSVAX B/E in Thailand is scientifically justified, morally correct, and strategically important. No laboratory assay or animal model has been validated as a predictor of the efficacy of HIV vaccines in humans, thus efficacy trials are essential to test bona fide vaccine hypotheses. Although there is a real chance that the prime-boost combination may not be efficacious, there is a very high probability that information gained will significantly advance HIV vaccine development. Established scientific principles and appropriate processes fully support the decision to proceed with this efficacy trial. [1]: http://www.sciencemag.org/cgi/content/full/303/5660/961 [2]: http://www.sciencemag.org/cgi/content/short/303/5656/316

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