Aspiration of Activated Charcoal

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To the Editor: Clinical practice in cases of serious overdose includes the administration of activated charcoal to decrease drug absorption from the gastrointestinal tract. There is also evidence that activated charcoal can decrease the serum half-life of ingested drugs, even after their absorption.1 In a recent prospective study of phenobarbital overdoses, repeated doses of activated charcoal significantly increased drug elimination but had no effect on the clinical course.2 Our institution has used repeated-dose charcoal therapy in an empiric manner. Overdoses of tricyclic antidepressants represent one of the most common serious drug overdoses.3 The following case illustrates the successful management of . . .

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