MEASLES TOXIN

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Abstract
This is a preliminary report of the preparation of measles toxin from a micro-organism isolated by us in pure culture from the blood of patients in the early stages of the disease. The micro-organism is characterized as a small, gram-positive, aerobic, green producing streptococcus, appearing both in pairs and in chains, which produces an extracellular or soluble toxin specific to measles. In obtaining this organism, about 10 cc. of blood, drawn directly from the median cephalic vein, was planted in 0.25 liter flasks of Hibler medium, incubated twenty-four hours and plated directly on sheep blood agar. The plates were incubated aerobically twenty-four hours and planted from that to blood agar slants or into 0.2 per cent glucose broth. The organism we have isolated differs from that described by Tunnicliff, in that it is an aerobe growing luxuriantly in the presence of oxygen and that it produces a soluble toxin specific

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