A Facile Solution Phase Combinatorial Synthesis of Tetrasubstituted Pyridines Using the Bohlmann-Rahtz Heteroannulation Reaction
- 23 November 2002
- journal article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 5 (1) , 41-44
- https://doi.org/10.1021/cc020067d
Abstract
The solution phase combinatorial Bohlmann-Rahtz reaction gives highly functionalized pyridine libraries from enamino esters and alkynones in a single synthetic step. Good product ratios and library purities were obtained in reactions catalyzed by zinc(II) bromide, the acid-catalyzed heteroannulation procedure offering considerable improvements over traditional methodology.Keywords
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