The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus
- 1 November 1993
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 19 (6) , 571-575
- https://doi.org/10.1007/bf01233383
Abstract
We have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescentin situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS).Keywords
This publication has 16 references indexed in Scilit:
- The human ubiquitin-activating enzyme E1 gene (UBE1) mapped to band Xp11.3→p11.23 by fluorescence in situ hybridizationCytogenetic and Genome Research, 1992
- CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1Nature, 1991
- Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome.The Journal of Experimental Medicine, 1991
- Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22–Xp11.3Genomics, 1991
- Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott–Aldrich syndromeNature, 1991
- Report of the committee on the genetic constitution of the X chromosome (Part 1 of 7)Cytogenetic and Genome Research, 1991
- Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosomeGenomics, 1990
- Translocation across golgi vesicle membranes: A CHO glycosylation mutant deficient in CMP-sialic acid transportCell, 1984
- Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.The Journal of Experimental Medicine, 1984
- SURFACE PROTEIN ABNORMALITIES IN LYMPHOCYTES AND PLATELETS FROM PATIENTS WITH WISKOTT-ALDRICH SYNDROMEThe Lancet, 1981