Effect of nitrogen source on nutritional management after small bowel resection in rats.

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Abstract
Nutritional effects of dietary N sources on rats subjected to 65% distal resection of the small bowel were compared at the 2.4% N level, i.e., by feeding the rats a diet which contains 2.4% N from various sources. The N sources used were casein (C), the casein-simulated amino acid mixture (F), the proposed amino acid mixture (T-2), which was devised in this laboratory, and the amino acid-casein mixture (R), in which 25% of the proposed amino acid mixture was replaced by isonitrogenous casein. All experimental diets were made cellulose-free. Total weight gains of the resected groups during 3 wk were less than those of the corresponding unresected groups because of the depressed gains in the 1st postoperative wk. In the resected and unresected rats, the maximum total weight gain was obtained with diet R and followed weight gains with diet C, diet F and diet T-2. Fecal weight increased moderately in the resected rats, but the degree of the increase was not influenced by the type of dietary N source. Dry weight of intestinal remnants increased markedly within 1 wk after resection. The extent of hyperplasia was not altered by the type of dietary N source. An amino acid mixture partially replaced with casein may be a useful dietary N source for short gut syndrome.

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