Hyponatremia and Vincristine Therapy
- 1 September 1966
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 112 (3) , 256-259
- https://doi.org/10.1001/archpedi.1966.02090120124015
Abstract
SCHWARTZ et al1 in 1957 described two patients with bronchogenic carcinoma who exhibited hyponatremia and excessive renal sodium loss. Metabolic studies in these patients gave results similar to those described in normal subjects receiving vasopressin (Pitressin). This syndrome has also been described in patients with tuberculosis, meningitis,2 myxedema,3 acute intermittent porphyria,4 and various diseases involving the central nervous system (CNS) (tumor, trauma, and vascular disease5,6). The syndrome was attributed to inappropriate secretion of antidiuretic hormone (ADH).1 The purpose of this report is to describe a patient who manifested hyponatremia and excessive renal sodium loss in conjunction with vincristine therapy for a rhabdomyosarcoma of the spermatic cord. Report of a Case The patient was first seen at the Childrens Hospital of Los Angeles in February 1965, at the age of 11 months because of a scrotal mass. The mass was first detected at the ageThis publication has 1 reference indexed in Scilit:
- Carcinoma of the Lung with Inappropriate AntidiuresisNew England Journal of Medicine, 1963