Conservation, evolution, and specificity in cellular control by protein phosphorylation
- 1 May 1996
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 52 (5) , 449-454
- https://doi.org/10.1007/bf01919314
Abstract
The glycolytic control enzyme phosphofructokinase from the parasitic nematodeAscaris lumbricodies is regulated by reversible phosphorylation. The enzyme is phosphorylated by an atypical cyclic adenosine monophosphate (cAMP)-dependent protein kinase whose substrate specificity deviates from that of the mammalian protein kinase. This variation is explained by structural peculiarities on the surface part of the catalytic groove of the protein kinase. Also, the protein phosphatases responsible for the reversal of phosphorylation appear to act specifically in glycolysis and are different from those participating in regulation of glycogenolysis.Keywords
This publication has 26 references indexed in Scilit:
- Comparison of the Substrate Specificities of cAMP-Dependent Protein Kinase from Bovine Heart andAscaris suumMuscleBiological Chemistry Hoppe-Seyler, 1996
- The Catalytic Subunit of cAMP-Dependent Protein Kinase from Ascaris suum. The Cloning and Structure of a Novel Subtype of Protein Kinase AEuropean Journal of Biochemistry, 1995
- Characterization of the major phosphofructokinase — dephosphorylating protein phosphatases from Ascaris suum muscleBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
- The Structure, Role, and Regulation of Type 1 Protein PhosphatasesCritical Reviews in Biochemistry and Molecular Biology, 1992
- Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseScience, 1991
- Protein serine/threonine phosphatases; an expanding familyFEBS Letters, 1990
- THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASESAnnual Review of Biochemistry, 1989
- The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic DomainsScience, 1988
- Reversible activation and inactivation of phosphofructokinase from Ascaris suum by the action of tissue-homologous protein phosphorylating and dephosphorylating enzymesBiochemical and Biophysical Research Communications, 1986
- Energy Metabolisms of Parasitic Helminths: Adaptations to ParasitismAnnual Review of Physiology, 1981