Adrenal Secretion After Bilateral Adrenalectomy for Cushing's Syndrome

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Abstract
Bilateral adrenalectomy has proved to be the treatment of choice at present for most patients with Cushing''s syndrome due to bilateral adrenal hyperplasia. Concern has always been felt when both adrenals are completely removed and supplementary steroid therapy is required throughout the life of the patient. The following report deals with an interesting syndrome[long dash]that of continued secretion of more than adequate quantities of corticosteroids by extra-adrenal cortical tissue following adrenalectomy. To distinguish between persistent extra-adrenal functioning tissue and the subsequent regeneration of cortical tissue, it is suggested that careful testing with ACTH under dexamethasone-maintenance therapy be carried out during the immediate postoperative period in all patients subjected to bilateral adrenalectomy.

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