Renoprival Hypertension and Antirenin

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Abstract
An antirenin titer of about 10 units/ml was produced in 1 dog by repeated injections of purified renin, and in 4 dogs was passively induced by injections of antirenin plasma in amounts of 2500 units/kg. Antirenin did not prevent development of renoprival hypertension in overhydrated nephrectomized dogs, or reduce it in normally hydrated renoprival hypertensive dogs, nor did it prevent the development of the typical arteriolonecrosis and multiple focal myocardial hemorrhagic necroses associated with renoprival hypertension. In the same dogs, pressor responses to injection of small or medium doses of renin were abolished. Large doses of renin caused pressor responses that resembled those of angio-tonin. In the same dogs, the pressor responses to acute ischemia of transplanted kidneys were greatly reduced. Renoprival hypertension and associated vascular changes are not attributable to renin, either residual or of extrarenal origin.