Partial exchange transfusion as treatment for hemoglobin SC disease in pregnancy

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Abstract
Serious infarctions and embolic events can complicate the course of pregnant patients with Hb SC disease. In 2 cases, partial exchange transfusion preceded recovery in severely ill pregnant women with Hb SC disease. There seem to be pathophysiological correlations for the observed clinical findings, and there are potential beneficial effects of partial exchange transfusion. Partial exchange transfusion should be considered as a means of reversing the often fatal complications attending Hb SC disease and pregnancy. The exchange should be of sufficient volume to ensure a postexchange level of Hb A of at least 30%.

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