A Carbon-13 Nuclear Magnetic Resonance Study of Binding of Copper(II) to Pyrimidine Nucleotides and Nucleosides
- 15 March 1974
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 52 (6) , 924-929
- https://doi.org/10.1139/v74-149
Abstract
The influence of paramagnetic Cu2+ ions on the proton decoupled 13C n.m.r. spectra of pyrimidine nucleosides and nucleotides has been studied. For 5′-CMP, the C5 resonance is broadened first on the addition of Cu2+ ions followed by the C2, C4, and C1′ resonances. From a comparison of the transverse and longitudinal relaxation rates of the base carbon nuclei due to the presence of Cu2+ ions, binding of Cu2+ to the N3 nitrogen of 5′-CMP is predicted. A similar broadening behavior is observed for 5′-UMP, 5′-TMP, cytidine, and uridine. This indicates that the Cu2+ ion is located near the N3 nitrogen in these Cu2+-nucleoside and -nucleotide complexes.Keywords
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