A New Approach to the Synthesis of 2-Aminopurine-2′-deoxyribosideviaTri-n-butyltin Hydride Reduction
- 1 August 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 14 (6) , 1445-1452
- https://doi.org/10.1080/15257779508010704
Abstract
A simple conversion of guanosine to 2-aminopurine-2′-deoxyriboside is described. Following the synthesis of the 2′-phenoxythiocarbonyl derivative of 6-chloroguanosine, 2-aminopurine-2′-deoxyriboside can be prepared by simultaneous reduction of both the 6- and 2′-position using tri-n-butyltin hydride as reducing agent. Several oligo-nucleotides containing 2-aminopurine-2′-deoxyriboside have been synthesized.Keywords
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