Effects of calcium antagonists on low density lipoprotein metabolism in human arterial smooth muscle cells.
- 1 January 1988
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 154 (4) , 329-333
- https://doi.org/10.1620/tjem.154.329
Abstract
Human arterial smooth muscle cells were used to study the effects of calcium antagonists on cellular interactoins with iodinated human low density lipoprotein ([125I]LDL). Both verapamil and nicardipine inhibited the degradation of internalized LDL, and as a result, facilitated the intracellular accumulation of LDL without accompanying the change in receptor binding of LDL. These results suggest that the effectiveness of calcium antagonists in improvement of atherosclerosis might not be due to the improvement of LDL metabolism against atherogenesis.This publication has 8 references indexed in Scilit:
- Effect of verapamil on accumulation of free and esterified cholesterol in the thoracic aorta of cholesterol-fed rabbitsAtherosclerosis, 1986
- The effect of calcium antagonists on the proteolytic degradation of low-density lipoprotein in HeLa cellsExperimental Cell Research, 1985
- Verapamil enhances receptor-mediated endocytosis of low density lipoproteins by aortic cells in culture.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Effect of calcium-channel-blocking drugs on lysosomal function in human skin fibroblastsBiochemical Pharmacology, 1984
- Effect of Ca2+ blocking agents on the metabolism of low density lipoproteins in human skin fibroblastsBiochemical and Biophysical Research Communications, 1982
- Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine.Journal of Clinical Investigation, 1981
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation, 1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951