Presence of Cortisol-Binding Protein in the Lens

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Abstract
The authors have verified the presence of cortisol-binding protein in the rat lens, using gel filtration and cortisol-4-[14C]. Two methods of isolation of the cortisol-binding protein were used – a precipitation method and DEAE chromatography. Cortisol-binding activity was found to be located mostly in the β-crystallin fraction in the soluble protein of the lens. The authors propose to call it cortisol-binding crystallin. The factors influencing the binding capacity for cortisol by crystallin in the lens have been studied, and a possible role is suggested for cortisol-binding by crystallin in the lens in the formation of steroid cataracts.

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