A Physicochemical Approach to the Study of Amines as Antiplaque Agents
- 1 January 1976
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 55 (1) , 130-134
- https://doi.org/10.1177/00220345760550010501
Abstract
Alkyl and aromatic amines and their salts were evaluated for inhibitory activity against Streptococcus mutans 6715. Antiplaque activity was correlated with the physicochemical properties, lipophilicity and basicity. The results indicate that the basicity of the amine is the primary requirement for activity. The lipophilic character then exerts a modulating effect on amines with the proper pKa values.This publication has 6 references indexed in Scilit:
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