Micronutrients and the Risk of Lung Cancer

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Abstract
To the Editor: The observation by Menkes et al. (Nov. 13 issue)1 that serum beta-carotene and vitamin E were inversely associated with the risk of lung cancer, and that retinol and selenium showed no relation, prompted us to investigate this question in an ongoing follow-up study of 10,532 subjects in the Netherlands.2 At the base-line examination of this cohort in 1975, risk factors for chronic diseases were measured and blood was collected and stored. In the subsequent nine years, 114 subjects died of cancer. Deaths in the first year of follow-up were excluded, as were eligible cases for which base-line . . .

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