Site-Specific Formation of A basic Lesions in DNA
- 1 October 1999
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 18 (10) , 2141-2146
- https://doi.org/10.1080/07328319908044871
Abstract
A method for the introduction of depurinated lesions in DNA is described, and is based on the formation of a covalent cross-link between an antisense oligonucleotide probe and the target DNA sequence followed by an unexpectedly mild thermal depurination.Keywords
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