The Effect of Drugs on the Motility of Isolated Strips of Human Stomach Muscle

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Abstract
Summary: Strips of longitudinal muscle were obtained from the anterior and posterior wall of the human stomach removed at gastrectomy for duodenal ulceration. The preparations were mounted in an isolated organ bath and movements recorded. Spontaneous movement included periods of relative quiescence, periods of slow wave changes in tonus, and periods of active contraction. Periods of tetanic spasm could be induced by drugs. Acetylcholine, carbaminoylcholine, eserine, barium and histamine stimulated the muscle, and adrenaline, ephedrine and amphetamine inhibited it. Atropine, pavatrine, benadryl and neoantergan (2786 RP) inhibited spontaneous and drug induced contractions. Small doses of atropine (concentration of 10−7) occasionally had a motor effect on the muscle strip. Morphine had no effect on the quiescent or actively contracting muscle, but increased the tone of the slow wave of tonus change. Irregularity of spontaneous activity and response to drugs was a marked feature of the preparation.