T Cell Replicative Senescence Pleiotropic Effects on Human Aging
- 1 June 2004
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1019 (1) , 123-126
- https://doi.org/10.1196/annals.1297.022
Abstract
Abstract: Long‐term culture studies using CD8 T cells, the immune cells responsible for control of viral infection, have identified the major features of replicative senescence. Aging is associated with increased proportions of CD8 T cells with similar characteristics, such as absence of expression of the CD28 costimulatory molecule and reduced antiviral effector functions. Proinflammatory cytokines produced by senescent CD8 T cells also may exert pleiotropic suppressive effects on overall immune function and bone homeostasis. Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age‐associated pathologies.Keywords
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