Photoreactivity of chlorpromazine with native DNA in an aqueous solution.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 21 (3/4) , 279-287
- https://doi.org/10.1269/jrr.21.279
Abstract
Near-UV irradiation of a mixture of chlorpromazine and native DNA caused irreversible binding of the drug or its photoproduct (s) to DNA and double strand break of DNA. When the irradiation was performed in a reaction mixture with a low salt concentration, much more photobinding occurred. Accompanying these effects, the maximum hyperchromicity of DNA at a high temperature was decreased. This can be explained by either a partial denaturation or an inhibition of melting by a formation of complex between double helical DNA and a promazine polymer.This publication has 4 references indexed in Scilit:
- pH dependence of the phototoxic and photomutagenic effects of chlorpromazineChemico-Biological Interactions, 1980
- Lichenoid Dermatitis due to Chlorpromazine PhototoxicityDermatology, 1979
- Photomutagenesis by chlorinated phenothiazine tranquilizers.Proceedings of the National Academy of Sciences, 1979
- Protein and enzyme release from human leukocytes: Influence of phenothiazine derivativesChemico-Biological Interactions, 1977