Conserved function for embryonic nodal cilia
- 1 July 2002
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 418 (6893) , 37-38
- https://doi.org/10.1038/418037a
Abstract
How left–right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate1,2. In mice, a left–right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node3,4. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.Keywords
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