Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by isopentenyl diphosphate:dimethylallyl diphosphate isomerase
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 8,p. 717-718
- https://doi.org/10.1039/a900621d
Abstract
The interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) catalyzed by E. coli and S. pombe IPP isomerase proceeds with removal of the pro-R proton at C2 of IPP and addition of a water-derived proton to the re face of the C2–C3 double bond in DMAPP; this is the same stereochemistry observed for S. cerevisiae and rat liver enzymes.Keywords
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