COMPARATIVE ANTIOESTROGENIC POTENCIES OF PROGESTERONE AND ESTERIFIED 17α-HYDROXY-PROGESTERONE IN THE GUINEA-PIG

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Abstract
SUMMARY: Five different antioestrogenic activities inherent in progestational compounds such as the antifibromatogenic, antihysterotrophic and antiluteinizing actions, the prevention of the oestrogen-induced opening of the vaginal membrane, and the counteracting of alopecia, have been investigated in the guinea-pig in experiments with 17α-hydroxyprogesterone and its caproate and acetate. These antioestrogenic properties are either not inherent in the above-mentioned compounds, or only inherent to a slight degree. The very slight antioestrogenic potency of 17 α-hydroxyprogesterone is not increased by esterification with either caproic or acetic acid. The clinical significance of these findings is discussed.