Glucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial Parasites
- 16 May 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3881) , 839-842
- https://doi.org/10.1126/science.164.3881.839
Abstract
Erythrocyte mosaicism occurs in females heterozygous for glucose-6-phosphate dehydrogenase deficiency. In blood from female children with acute Plasmodium falciparum malaria the parasite rate was 2 to 80 times higher in normal than in deficient erythrocytes. This may be the mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria.Keywords
This publication has 25 references indexed in Scilit:
- GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY, SICKLING, AND MALARIA IN AFRICAN CHILDREN IN SOUTH WESTERN NIGERIAThe Lancet, 1967
- Different properties of glucose 6-phosphate dehydrogenase from human erythrocytes with normal and abnormal enzyme levelsBiochemical and Biophysical Research Communications, 1965
- Glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in South African Bantu infantsThe Journal of Pediatrics, 1964
- Genetic variations in the quantitative control of erythrocyte glucose‐6‐phosphate dehydrogenase activityAnnals of Human Genetics, 1964
- Genetic Tests with a Sex-Linked Marker: Glucose-6-Phosphate DehydrogenaseCold Spring Harbor Symposia on Quantitative Biology, 1964
- Malaria in African Children with Deficient Erythrocyte Glucose-6-phosphate DehydrogenaseBMJ, 1961
- The initial progress of new genes with viability differences between sexes and with sex linkageHeredity, 1961
- Glucose-6-Phosphate Dehydrogenase Deficiency in Red Blood Cells of East AfricansNature, 1960
- Stable Equilibrium at a Sex-linked LocusNature, 1959
- Blood examination and prognosis in acute falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1949