Administration of Endotoxin Associated with Lipopolysaccharide Tolerance Protects Mice against Fungal Infection
Open Access
- 1 June 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (6) , 3748-3753
- https://doi.org/10.1128/iai.68.6.3748-3753.2000
Abstract
Lipopolysaccharide (LPS) pretreatment of mice resulted in a significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of cytokines in blood, spleen, and lungs and higher levels in brain. Pentoxifylline abolished the beneficial effect of LPS pretreatment.Keywords
This publication has 37 references indexed in Scilit:
- Lipopolysaccharide Pretreatment Protects from Renal Ischemia/Reperfusion InjuryThe American Journal of Pathology, 2000
- Enhanced Sensitivity of Tumor Necrosis Factor/Lymphotoxin‐α–Deficient Mice toCryptococcus neoformansInfection despite Increased Levels of Nitrite/Nitrate, Interferon‐γ, and Interleukin‐12The Journal of Infectious Diseases, 1999
- Dissociation of IFN-γ from IL-12 and IL-18 production during endotoxin toleranceInnate Immunity, 1999
- Sensitization to Lipopolysaccharide in Mice with Asymptomatic Viral Infection: Role of T Cell‐Dependent Production of Interferon–γThe Journal of Infectious Diseases, 1997
- Ex vivo effects of macrophage colony-stimulating factor on human monocyte activity against fungal and bacterial pathogensCytokine, 1996
- Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβInnate Immunity, 1994
- Pre‐exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activityEuropean Journal of Immunology, 1993
- Tolerance to Endotoxin Prevents Mortality in Infected Thermal Injury: Association with Attenuated Cytokine ResponsesThe Journal of Infectious Diseases, 1992
- Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.The Journal of Experimental Medicine, 1990
- Interferon Appearance Stimulated by Endotoxin, Bacteria, or Viruses in Mice Pre-Treated with Escherichia coli Endotoxin or Infected with Mycobacterium tuberculosisNature, 1965