ASSOCIATION BETWEEN RISE IN ANTIBODIES AND INCREASE IN AIRWAY SENSITIVITY AFTER INTRAMUSCULAR INJECTION OF KILLED INFLUENZA-VIRUS IN ASTHMATIC-PATIENTS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 66  (4) , 268-272
Abstract
Stable asthmatic patients (19) were given killed influenza virus i.m. In 9 patients who developed a 4-fold or greater rise in hemagglutination antibodies, an increase in airway sensitivity to histamine was demonstrated 48 h later. There was no significant change in histamine sensitivity in those patients who failed to develop a 4-fold rise in hemagglutination antibodies. The increased histamine sensitivity was not associated with a deterioration in asthma symptoms, peak expiratory flow nor an increase in bronchodilator requirements.

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