Human Anti-insulin Antibodies

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Abstract
Summary: Sera from 50 insulin-treated diabetics were studied for antibodies against insulin. Antiinsulin titers were measured by the degree of insulin 131I binding, and biochemical classes of anti-insulin antibodies were defined using radioimmunoelectrophoresis. The most common type of anti-insulin immunoglobulin was IgG (40 patients). Nine patients had IgA anti-insulin antibodies, and the rarest antibody was IgM. IgG antibodies correlated with anti-insulin titers, but IgA and IgM did not. Insulin-anti-insulin immune complexes were demonstrated in the sera of four patients. Antigen-antibody complexes are suggested to be a pathogenetic factor in the microvasculitis of diabetes.

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