POSSIBLE MECHANISMS OF ACTION OF LITHIUM ON AUGMENTATION OF INVITRO SPONTANEOUS MYELOID COLONY FORMATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (8) , 3215-3219
Abstract
To understand the possible mechanisms of lithium carbonate-induced neutrophilia, the in vitro effect on human myeloid progenitor cells was examined. A significant increase in spontaneous colony formation (15 of 24 experiments) was observed with the addition of Li. Increased colony formation seldom occurred when human placental conditioned media as a source of colony-stimulating activity (CSA) was simultaneously added to the cultures. Li apparently requires an adherent marrow cell population for this action and increases in CSA-containing cultures may be due to suboptimal CSA concentrations. Li released CSA from marrow cells and adherent cell populations prepared from human bone marrow. Li possibly increases spontaneous human myeloid colony development indirectly through CSA release by adherent cells. [These results have relevance to use of Li to ameliorate chemotherapy-induced myelosuppresion in cancer patients.].

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