Female Sex and Higher Drug Dose as Risk Factors for Late Cardiotoxic Effects of Doxorubicin Therapy for Childhood Cancer
Open Access
- 29 June 1995
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 332 (26) , 1738-1744
- https://doi.org/10.1056/nejm199506293322602
Abstract
Late cardiotoxic effects of doxorubicin are increasingly a problem for patients who survive childhood cancer. Cardiotoxicity is often progressive, and some patients have disabling symptoms. Our objective was to identify risk factors for late cardiotoxicity.Keywords
This publication has 35 references indexed in Scilit:
- Female gender as a risk factor for torsades de pointes associated with cardiovascular drugsJAMA, 1993
- Central Nervous System Disease in Childhood AllPediatric Hematology and Oncology, 1993
- Electrocardiographic changes and arrhythmias after cancer therapy in children and young adultsThe American Journal of Cardiology, 1992
- Influence of Doxorubicin Dose Intensity on Response and Outcome for Patients With Osteogenic Sarcoma and Ewing's SarcomaJNCI Journal of the National Cancer Institute, 1991
- Experience with Multiagent Chemotherapy for OsteosarcomaPublished by Wolters Kluwer Health ,1991
- Sexual differences in cancer survival: hormones or stage at diagnosis?JAMA, 1990
- Long term doxorubicin cardiotoxicity in childhood: non-invasive evaluation of the contractile state and diastolic filling.Heart, 1988
- Prospective evaluation of doxorubicin cardiotoxicity by rest and exercise radionuclide angiographyThe American Journal of Cardiology, 1986
- The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the ExtremityNew England Journal of Medicine, 1986
- Revised standards for triceps and subscapular skinfolds in British children.Archives of Disease in Childhood, 1975