A model of muscle atrophy using cast immobilization in mice
- 7 October 2005
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 32 (5) , 672-674
- https://doi.org/10.1002/mus.20399
Abstract
We describe a new cast‐immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains. Muscle Nerve, 2005Keywords
This publication has 12 references indexed in Scilit:
- Muscle Adaptations with Immobilization and Rehabilitation after Ankle FractureMedicine & Science in Sports & Exercise, 2004
- Acute molecular responses of skeletal muscle to resistance exercise in able-bodied and spinal cord-injured subjectsJournal of Applied Physiology, 2003
- Changes in muscle mass, fat mass, and bone mineral content in the legs after stroke: a 1 year prospective studyBone, 2001
- Mechanisms leading to restoration of muscle size with exercise and transplantation after spinal cord injuryAmerican Journal of Physiology-Cell Physiology, 2000
- Contribution of satellite cells to IGF‐I induced hypertrophy of skeletal muscleActa Physiologica Scandinavica, 1999
- Mechanism of specific force deficit in the senescent rat diaphragmRespiration Physiology, 1997
- Benefits of Aerobic Exercise After StrokeSports Medicine, 1996
- Contractile properties of skeletal muscles from young, adult and aged mice.The Journal of Physiology, 1988
- Rehabilitation of the neurologically disabled patient: principles, practice, and scientific basisJournal of Neurosurgery, 1983
- The purification of cardiac myofibrils with Triton X-100Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1971