CHEMICAL MARKERS OF MUCOUS AND SERUM GLYCOPROTEINS AND THEIR RELATION TO VISCOSITY IN MUCOID AND PURULENT SPUTUM FROM VARIOUS HYPER-SECRETORY DISEASES

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Abstract
Mucus and serum are present in the sputum. The concentrations of their markers were measured in mucoid and purulent sputum from patients with chronic bronchitis, asthma, cystic fibrosis or bronchiectasis. Differences in the concentrations of both mucous and serum glycoproteins were greater among different macroscopic types of sputum than among diseases for the same macroscopic type. Comparison between diseases showed that sputum from patients with asthama had the widest variation in concentrations of markers of mucous glycoprotein and dry macromolecular weight. When the asthma group was further analyzed, it became apparent that patients with extrinsic asthma without chronic bronchitis represented a homogeneous group, and those with intrinsic asthma, with or without chronic bronchitis, were responsible for the wide variation. The concentrations of markers of mucous and serum glycoproteins in a sputum sample were correlated with the apparent viscosity of the sputum to establish the relative contribution of the glycoproteins to the viscosity of sputum. In mucoid sputum, the mucous glycoprotein was most important in determining the viscosity; in infected sputum, both mucous and serum components contributed to the viscosity.