Treatment of Uncomplicated Gonorrhea with Amoxicillin

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Abstract
Amoxicillin was administered to male and female patients with gonorrhea that was confirmed by culture. Cure rates were 84% with a 1.0-g dose; when 3.0 g of amoxicillin was administered as a single dose, the cure rate was 95%, and it was 100% if the 3.0 g was given in several doses over a four-day period. This cure rate is equivalent to that achieved with either 4.8 × 106 units of intramuscular procaine penicillin and 1.0 g of probenecid or with 3.5 g of oral ampicillin and 1.0 g of probenecid. Amoxicillin in a single 3.0-g dose is effective in treating gonorrhea.

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