Androgen Target Cells in the Bursa of Fabricius of the Chick Embryo: Autoradiographic Localization

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Abstract
After i.v. injection of [3H]testosterone in 15 day old chick embryo, nuclear concentration of radioactivity is observed in mesenchymal cells of the bursa of Fabricius. In competition experiment with excess of unlabeled testosterone, the concentration of radioactivity is abolished, but not with unlabeled estradiol. When [3H]estradiol is injected alone, no nuclear concentration of radioactivity is observed in the bursa of Fabricius. Target cells for androgen in the bursa of Fabricius evidently exist. Androgens may be involved in the development and functioning of the immune system.