Intrarenal Blood Flow in Dogs with Normal and Spontaneously Elevated Blood Pressure

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Abstract
Intrarenal blood flow distribution was evaluated in 60 dogs with radiola-beled microspheres. The range of mean arterial blood pressure (BP) was 90 to 180 mm Hg, with an average of 137 mm Hg± 20 (SE). A poor but significant inverse correlation was found between renal blood flow (RBF) per gram kidney weight and the spontaneously occurring mean systemic pressure (r = −0.24, P < 0.001). Analysis of blood flow rates per gram inner and outer cortex showed substantially lower inner cortical flows in dogs with elevated blood pressure compared to dogs with lower blood pressures; outer cortical flow was essentially equivalent in the 60 animals. The correlation coefficient between inner cortical flow and BP was −0.534 (P < 0.001). Both inner and outer cortical resistance to flow increased significantly with pressure (P < 0.001). Electrolyte excretion rates (Na+ and K+) did not vary substantially in this population of dogs. These results demonstrate that spontaneously elevated blood pressure is associated with a specific reduction in inner cortical blood flow.

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