Effects of 3-methyl-5-isoxazole Carboxylic Acid on the Plasma Volume Loss Induced by Thermal Trauma

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Abstract
The effects of 3-methyl-5-isoxazole carboxylic acid (MIC) on postburn plasma volume loss were studied in the anesthetized dog, and the results demonstrated that, when administered before thermal trauma, MIC significantly reduces the plasma volume loss observed at 1 and 2 h postburn. The reduction of plasma volume loss observed was less than that observed with nicotinic acid administered preburn. A single 0.2-mg dose of MIC/kg body weight given 2 1/2 h after a 15% body surface area 3rd-degree flame burn significantly reduced the plasma volume loss during the next 4 h. This effect of MIC was approximately the same as that observed with nicotinic acid under the same conditions. The differences between nicotinic acid and MIC under these conditions were the size of the dose of drug required (0.2 mg/kg of MIC vs. 15 mg/kg of nicotinic acid) and the duration of action of the drug (> 3 h for MIC vs. 1 h for nicotinic acid).