The bromination of 2‐aminopyridine in the gas phase at 500°

Publisher Website
Google Scholar
Abstract
When 2‐aminopyridine and bromine in the form of vapour diluted with nitrogen are passed over pumice at 500°, a violent reaction takes place, much carbon is deposited and a complex mixture of brominated aminopyridines is formed.3 isomeric monobromo‐compounds could be isolated from the mixture, i.e. 2‐amino‐3‐bromopyridine, 2‐amino‐5‐bromopyridine and 2‐amino‐6‐bromopyridine. It contained further 3 dibromo‐compounds (2‐amino‐3,5‐dibromopyridine, 2‐amino‐3,6‐dibromo‐pyridine and 2‐amino‐5,6‐dibromopyridine) and one tribromo‐compound (2‐amino‐3,5,6‐tribromopyridine).The reaction described differs considerably from the bromination of 2‐amino‐pyridine at room temperature, by the last process a mixture of only 2‐amino‐5‐bromo‐pyridine and 2‐amino‐3,5‐dibromopyridine being formed.