EFFECT OF HYDROCHLOROTHIAZIDE ON URINE SATURATION WITH BRUSHITE, INVITRO COLLAGEN CALCIFICATION BY URINE, AND URINARY INHIBITORS OF COLLAGEN CALCIFICATION

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 118  (7) , 792-797
Abstract
The effect of short-term hydrochlorothiazide therapy on urine saturation with brushite (CaHPO4 .cntdot. 2H2O), in vitro collagen calcification by urine, and urinary inhibitors of calcification was studied. In 22 patients with idiopathic calcium oxalate/phosphate stones the urine calcium excretion decreased, urine Mg excretion increased and urine Mg/Ca ratio increased significantly (P < 0.001) during hydrochlorothiazide therapy. Supersaturation of the urine with brushite, which was present in 19 of 22 patients, was reduced significantly (P < 0.001) in all during thiazide therapy, and to the undersaturated range in 16. Ability of urine to calcify collagen in vitro decreased significantly (P < 0.001) during thiazide therapy, a change that correlated significantly (r [correlation coefficient] = 0.4513, P < 0.05) with the decrease in brushite saturation. Concentration of urinary inhibitors of calcification, as determined with an in vitro collagen calcification system, was decreased significantly (P < 0.01) by thiazide therapy. Thiazide diuretics decrease urinary brushite saturation and may prevent spontaneous nucleation or crystal growth, or both, of calcium phosphate.