Radiation-induced apoptosis
Top Cited Papers
- 23 March 2000
- journal article
- review article
- Published by Springer Nature in Cell and tissue research
- Vol. 301 (1) , 133-142
- https://doi.org/10.1007/s004410000188
Abstract
Radiation-induced apoptosis has been a topic of intense research during the last decade. Its recognition as a significant component of radiation-induced cell death has initiated several lines of investigation aimed at modulating the apoptotic response and thereby radiosensitivity. These strategies require the integration of both classical radiobiological concepts and the knowledge of the biochemical and molecular biological mechanisms involved in apoptosis induction. This review discusses mechanisms of radiation-induced apoptosis and highlights the radiobiological and radiotherapeutical relevance of this mode of cell death.Keywords
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