The Role of the Pituitary in the Aging of Collagen

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Abstract
The survival curve of 38 female rats after hypophysectomy at the age of 1 1/2 month confirms observations of others. Fifty per cent survival is 330 days and maximal survival 720 days for about 5%. This is about 1/2 of the life duration of normal rats. Collagen fibers of tail tendons after hypophysectomy, tested with heat denaturation tension show at every age 1/5-1/3 lower values than normals. Aging still occurs, but slower than in normals. Collagen of the skin (corium) similarly shows aging but this is also considerably diminished in velocity. Differences between dorsal and ventral skin were noted and explained by growth of ventral skin in the normal grown-up rat.

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