l‐DOPA Cytotoxicity to PC12 Cells in Culture Is via Its Autoxidation

1 February 1995

journal article
research article
Published by Wiley in Journal of Neurochemistry

Vol. 64 (2) , 825-832
https://doi.org/10.1046/j.1471-4159.1995.64020825.x

Abstract

The mechanism of cytotoxicity of l-DOPA was studied in the rat pheochromocytoma PC12 cell line. The cytotoxicity of l-DOPA to PC12 cells was time and concentration dependent. Carbidopa, whi...

Keywords

NEUROTOXICITY
DOPAMINE
PARKINSON'S DISEASE