Parallel Secretion of Calcium and Enzymes by the Human Pancreas

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Abstract
Secretion of calcium, bicarbonate and 4 pancreatic hydrolases into the duodenal juice were studied in groups of normal subjects (18), Subjects with cholecystectomy (9), and chronic pancreatic insufficiency (10). The pancreas was stimulated by a constant infusion of secretin (1 U/kg/h) which resulted in a plateau of secretion after about 30 min. An injection of pancreozymin (1 U/kg) followed after 60 min. This produced a significant increase in concentration and output of both calcium and enzymes. Both parameters were positively correlated. In cases with cholecystectomy, pancreozymin produced a similar parallel increase of secretion of calcium and enzymes. Since the influx of the bile into the duodenum was not changed, the amount of calcium stimulated by pancreozymin in the pancreas could be calculated at 5.2 μEq/min. In the group with pancreatic insufficiency, pancreozymin failed to evoke any increased secretion of calcium and enzymes. The resultsindicate that calcium enters human pancreatic juice in close association with pancreatic enzyme protein.

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