Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury?

  • 26 June 2000
    • journal article
    • review article
    • Vol. 11  (9) , R1-4
Abstract
Nuclear factor-kappaB (NF-kappaB) is a transcription factor which resides in its unactivated form in the cytoplasm. Following activation subsequent to cerebral ischemia and reperfusion injury, NF-kappaB acts on genes for cytokines, adhesion molecules, nitric oxide synthase, cyclooxygenase-2, metalloproteinase-9, and perhaps apoptotic genes. These genes have a variety of positive and negative influences on the outcome of brain injury. The effect of manipulation of NF-kappaB needs to be examined critically, as it pertains to these reactive genes.

This publication has 0 references indexed in Scilit: