Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer
- 15 October 1991
- Vol. 68 (8) , 1799-1802
- https://doi.org/10.1002/1097-0142(19911015)68:8<1799::aid-cncr2820680825>3.0.co;2-3
Abstract
Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast-like differentiation are reported. The multinucleated, syncytiotrophoblast-like cells were strongly positive for β-human chorionic gonadotropin (β-HCG) by immunohistochemical study. High levels of β-HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor.Keywords
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