Chemical modifications of the aliphatic bridge of ansamycins. Synthesis and activity of 25-deacetoxy-25-epi-hydroxyrifamycin S.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (5) , 516-521
- https://doi.org/10.7164/antibiotics.36.516
Abstract
To increase the intrinsic activity of rifamycin S, the 25-deacetoxy-25-epi-hydroxyrifamycin S, which displays an additional hydroxyl available for the inhibiting interaction with bacterial enzyme was synthesized. The configuration and conformation of the new compound were as expected; the biological activity against Escherichia coli was not as expected.This publication has 1 reference indexed in Scilit:
- Comparative study of the conformations of rifamycins in solution and in the solid state by proton nuclear magnetic resonance and x-raysThe Journal of Organic Chemistry, 1982