A protein of the endoplasmic reticulum involved early in polypeptide translocation
- 1 May 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 357 (6373) , 47-52
- https://doi.org/10.1038/357047a0
Abstract
To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.Keywords
This publication has 29 references indexed in Scilit:
- Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae.The Journal of cell biology, 1992
- A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation.The Journal of cell biology, 1991
- A yeast mitochondrial outer membrane protein essential for protein import and cell viabilityNature, 1990
- Photocrosslinking demonstrates proximity of a 34 kDa membrane protein to different portions of preprolactin during translocation through the endoplasmic reticulumFEBS Letters, 1989
- Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.The Journal of cell biology, 1989
- A 42K outer-membrane protein is a component of the yeast mitochondrial protein import siteNature, 1989
- A signal sequence receptor in the endoplasmic reticulum membraneNature, 1987
- The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particleNature, 1986
- Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.The Journal of cell biology, 1982
- Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.The Journal of cell biology, 1981